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No particular dose adjustment encouraged when tofacitinib coadministered with powerful CYP2C19 inhibitors; lessen tofacitinib dose if coadministered with each moderate CYP3A4 and potent CYP2C19 inhibitors .modafinil will raise the stage or result of rabeprazole by impacting hepatic enzyme CYP2C19 metabolism. Slight/Significance Unfamiliar. Web effe